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Within the earlier assessment, squalene is proven to reduce MPO while increasing HO-step one gene term inside the people neutrophils and you will monocytes addressed with LPS. MPO is actually an individual necessary protein receive mainly inside the neutrophil azurophilic granules and you may monocyte lysosomes [85, 86, 87]. The outcome show that immediately after 18 h away from therapy with 50 M squalene, the new mRNA amount of MPO within the LPS-addressed person monocytes and you will neutrophils diminished (P 0.001).

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